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Case Reports
. 1978 Jul;35(7):423-5.
doi: 10.1001/archneur.1978.00500310025005.

Polyneuropathy in Waldenström's macroglobulinemia. Deposition of M component on myelin sheaths

J Julien, C Vital, J M Vallat, A Lagueny, C Deminiere, D Darriet
Case Reports

Polyneuropathy in Waldenström's macroglobulinemia. Deposition of M component on myelin sheaths

J Julien et al. Arch Neurol. 1978 Jul.

Abstract

A chronic sensory neuropathy was the initial symptom in a case of Waldenström's macroglobulinemia in a 53-year-old woman. Ultrastructural analysis of a biopsied peripheral nerve revealed a modification of the lamellar structure of the myelin sheath. Immunofluorescent microscopy showed IgM-positive deposits on the myelin sheath. The monoclonal globulin (M component) present in the myelin appears to be a causative factor in the neuropathy.

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