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. 2010 Dec;8(12):1042-7.
doi: 10.1016/j.cgh.2010.09.007. Epub 2010 Sep 17.

Patients with celiac disease and B-cell lymphoma have a better prognosis than those with T-cell lymphoma

Thorvardur R Halfdanarson  1 , Alberto Rubio-Tapia, Kay M Ristow, Thomas M Habermann, Joseph A Murray, David J Inwards
Affiliations

Patients with celiac disease and B-cell lymphoma have a better prognosis than those with T-cell lymphoma

Thorvardur R Halfdanarson et al. Clin Gastroenterol Hepatol. 2010 Dec.

Abstract

Background & aims: Celiac disease (CD) is associated with an increased risk of lymphoma. However, relatively few studies have assessed the outcome of patients diagnosed with both CD and lymphoma. We evaluated the temporal association between lymphoma and CD, along with clinical presentation, response to therapy, and prognosis.

Methods: Patients diagnosed with both CD and lymphoma were identified retrospectively in a tertiary referral center. Clinical characteristics and survival were analyzed.

Results: Sixty-three patients (36 men) were identified who had been diagnosed with lymphoma and CD. Thirty-six (57%) were diagnosed with CD before they were diagnosed with lymphoma. The most common histologic entity was diffuse, large, B-cell lymphoma, which affected 18 (29%) patients. Complete information for staging was available in 59 patients; 24 (38%) had stage IV disease. Only chemotherapy or only radiation therapy was used for 43 (68%) and 11 (17%) patients, respectively. The 5- and 10-year cumulative survival rates for the entire cohort were 58% and 39%, respectively. Survival of patients with T-cell lymphoma was shorter than for all other lymphomas (119.4 vs 22.8 mo; P = .02).

Conclusions: CD is associated with B- and T-cell lymphomas. Patients with B-cell lymphomas had a better prognosis than those with T-cell lymphoma. Therapy is unsatisfactory for enteropathy-type T-cell lymphoma.

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Conflict of interest statement

Conflicts of interest: The authors disclose no conflicts.

Figures

Figure 1
Figure 1
Cumulative survival by Kaplan–Meier analysis for the (A) entire cohort and according to (B) lymphoma subtype.
See this image and copyright information in PMC

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