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. 1990 Nov;31(3-4):275-9.
doi: 10.1007/BF01997619.

Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells

M Bianchi  1 , A Mantovani, A Erroi, C A Dinarello, P Ghezzi
Affiliations

Ambroxol inhibits interleukin 1 and tumor necrosis factor production in human mononuclear cells

M Bianchi et al. Agents Actions. 1990 Nov.

Abstract

We have studied the effect of Ambroxol on the production of Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) in human mononuclear cells (MNC). For this purpose MNC were cultured for 24 h in the presence of endotoxin and different doses of Ambroxol. The results indicate that Ambroxol markedly inhibited IL-1 and TNF production at doses of 10-100 microgram ml, without any apparent toxicity.

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