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Review
. 2010 Aug;71(8):451-6.
doi: 10.12968/hmed.2010.71.8.77669.

Sorafenib in hepatocellular carcinoma

Debra H Josephs  1 , Paul J Ross
Affiliations
Review

Sorafenib in hepatocellular carcinoma

Debra H Josephs et al. Br J Hosp Med (Lond). 2010 Aug.

Abstract

Sorafenib, a small molecule multikinase inhibitor, is the standard of care in the USA and Europe for the treatment of advanced hepatocellular carcinoma. This article reviews its development from the basis of molecular hepatocarcinogenesis to phase III trials and discusses the future for sorafenib in hepatocellular carcinoma.

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