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Case Reports
. 2010 Aug;48(2):173-6.
doi: 10.3340/jkns.2010.48.2.173. Epub 2010 Aug 31.

Undetermined fibrous tumor with calcification in the cerebellopontine angle

Se Hun Cheon  1 , Shin-Hyuk Kang, Kyung Jae Park, Yong Gu Chung
Affiliations
Case Reports

Undetermined fibrous tumor with calcification in the cerebellopontine angle

Se Hun Cheon et al. J Korean Neurosurg Soc. 2010 Aug.

Abstract

In this report, we introduce an undetermined fibrous tumor with calcification occurring in the cerebellopontine angle (CPA). A 51-year-old woman was admitted with a short history of dizziness. Computed tomography and magnetic resonance images revealed a 2×2×2 cm sized mass at the left CPA which was round and calcified. There was no dura or internal auditory canal involvement. At surgery, the tumor was located at the exit of 7th and 8th cranial nerve complex. It was very firm, bright yellow and well encapsulated. Histologic findings revealed that the tumor was predominantly composed of fibrous component, scant spindle cells and dystrophic calcification. Immunohistochemical staining demonstrated positive for vimentin and negative for epithelial membrane antigen (EMA), S-100 protein, CD34, factor XIIIa and smooth muscle actin. The diagnosis was not compatible with meningioma, schwannoma, metastatic brain tumors, and other fibrous tumors. Although the tumor was resected in total, long term follow-up monitoring is necessary due to the possibility of recurrence.

Keywords: Calcification; Cerebellopontine angle; Immunohistochemistry; Tumor.

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Figures

Fig. 1
Fig. 1
In computed tomography, calcifying mass is seen at left cerebellopontine angle region (A) and T2-weighted magnetic resonance (MR) image shows hypointense lesion on left cerebellopontine angle (CPA) (B). The axial (C) and coronal (D) gadolinium enhancement MR images show isointense lesion with minimal enhancement on left CPA and there is no dural enhancement or internal auditory involvement of the tumor.
Fig. 2
Fig. 2
The tumor is bright yellow and well circumscribed and it is not adhered to tentorium (T). A : Supeior petrosal vein (arrow) and 9th nerve (curved arrow) are observed. B : After tumor removal, arachnoid adhesion (arrow) adjacent to the exit of the 7th and 8th nerve complex (arrow head) is observed.
Fig. 3
Fig. 3
Histopathological examination shows dystrophic calcification (arrow) and spindle cells (H&E,×400) (A). Immunohistochemistry for vimentin is positive (B).
Fig. 4
Fig. 4
T2-weighted (A) and gadolium enhanced T1-weighted (B and C) MR images checked 6 months after the surgery show no remnant or recurrence.
See this image and copyright information in PMC

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