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. 2010 Sep 28;16(36):4616-20.
doi: 10.3748/wjg.v16.i36.4616.

Clinicopathological features of gastric glomus tumor

Hui-Qiong Fang  1 , Jing Yang, Fen-Fen Zhang, Yi Cui, An-Jia Han
Affiliations

Clinicopathological features of gastric glomus tumor

Hui-Qiong Fang et al. World J Gastroenterol. .

Abstract

Aim: To study the clinicopathological features of gastric glomus tumor and review the related Chinese literature published in 1990-2010.

Methods: A case of gastric glomus tumor was reported. Clinicopathological findings in 56 cases of gastric glomus tumor were analyzed.

Results: Gastric glomus tumor was far more common in women than in men with a female to male ratio of 1.6:1. The median age of the patients was 45 years (range 28-79 years). The patients often complained of epigastric pain and bloody stool. The tumor was located in antrum of the stomach. The greatest diameter of the tumor was 0.8-11 cm. Histologically, the tumor was comprised of nests of glomus cells surrounding the capillaries. Glomus cells were small, uniform and round. Vimentin, smooth muscle actin and actin were expressed in the tumor. Other markers, including S-100 protein, CD34, CD117, desmin, CD56, synaptophysin, chromogranin A, neuron specific enolase and cytokeratin were all negative.

Conclusion: Gastric glomus tumor is a rare benign mesenchymal neoplasm. Its diagnosis depends on pathologic examination. Differential diagnosis includes gastrointestinal stromal tumor, paraganglioma and carcinoid tumor.

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Figures

Figure 1
Figure 1
Upper gastrointestinal endoscopy showing a well-circumscribed elevated mass lesion measuring 1.5 cm × 1.5 cm with normal overlying mucosa in anterior wall of gastric corpus.
Figure 2
Figure 2
Endoscopic ultrasonography showing a 1.5 cm × 1.2 cm sharply demarcated homogeneous hypoechoic mass in the third and fourth sonographic layers of gastric wall.
Figure 3
Figure 3
Gastric glomus tumor. A: Glomus tumor located in the muscularis of stomach (hematoxylin-eosin × 40); B: Clusters of uniform, round tumor cells around dilated blood vessels (hematoxylin-eosin × 200); C: Tumor cells positive for smooth muscle actin (immunohistochemistry staining × 200).
Figure 4
Figure 4
Distribution of age in 57 cases of gastric glomus tumor. The age distribution of 57 cases of gastric glomus tumors
See this image and copyright information in PMC

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