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Review
. 2011 Jun;7(2):434-45.
doi: 10.1007/s12015-010-9192-8.

Stem cell-based therapeutic applications in retinal degenerative diseases

Yiming Huang  1 , Volker Enzmann, Suzanne T Ildstad
Affiliations
Review

Stem cell-based therapeutic applications in retinal degenerative diseases

Yiming Huang et al. Stem Cell Rev Rep. 2011 Jun.

Abstract

Retinal degenerative diseases that target photoreceptors or the adjacent retinal pigment epithelium (RPE) affect millions of people worldwide. Retinal degeneration (RD) is found in many different forms of retinal diseases including retinitis pigmentosa (RP), age-related macular degeneration (AMD), diabetic retinopathy, cataracts, and glaucoma. Effective treatment for retinal degeneration has been widely investigated. Gene-replacement therapy has been shown to improve visual function in inherited retinal disease. However, this treatment was less effective with advanced disease. Stem cell-based therapy is being pursued as a potential alternative approach in the treatment of retinal degenerative diseases. In this review, we will focus on stem cell-based therapies in the pipeline and summarize progress in treatment of retinal degenerative disease.

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Figures

Figure 1
Figure 1
CD8+/TCR− FC are a heterogeneous cell population, with the predominant subpopulation resembling B220+/CD11c+/CD11b− p-pre DC. Other subpopulations include CD19+, NK1.1+/DX5+ and CD3ε+. FC has been shown to induce Treg generation in vivo and in vitro.
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