Comment on

• Localized Rac activation dynamics visualized in living cells.

  Kraynov VS, Chamberlain C, Bokoch GM, Schwartz MA, Slabaugh S, Hahn KM. Kraynov VS, et al. Science. 2000 Oct 13;290(5490):333-7. doi: 10.1126/science.290.5490.333. Science. 2000. PMID: 11030651
• Coordination of Rho GTPase activities during cell protrusion.

  Machacek M, Hodgson L, Welch C, Elliott H, Pertz O, Nalbant P, Abell A, Johnson GL, Hahn KM, Danuser G. Machacek M, et al. Nature. 2009 Sep 3;461(7260):99-103. doi: 10.1038/nature08242. Epub 2009 Aug 19. Nature. 2009. PMID: 19693013 Free PMC article.
• A genetically encoded photoactivatable Rac controls the motility of living cells.

  Wu YI, Frey D, Lungu OI, Jaehrig A, Schlichting I, Kuhlman B, Hahn KM. Wu YI, et al. Nature. 2009 Sep 3;461(7260):104-8. doi: 10.1038/nature08241. Epub 2009 Aug 19. Nature. 2009. PMID: 19693014 Free PMC article.
• Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish.

  Yoo SK, Deng Q, Cavnar PJ, Wu YI, Hahn KM, Huttenlocher A. Yoo SK, et al. Dev Cell. 2010 Feb 16;18(2):226-36. doi: 10.1016/j.devcel.2009.11.015. Dev Cell. 2010. PMID: 20159593 Free PMC article.
• Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo.

  Wang X, He L, Wu YI, Hahn KM, Montell DJ. Wang X, et al. Nat Cell Biol. 2010 Jun;12(6):591-7. doi: 10.1038/ncb2061. Epub 2010 May 16. Nat Cell Biol. 2010. PMID: 20473296 Free PMC article.
• Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics.

  Grashoff C, Hoffman BD, Brenner MD, Zhou R, Parsons M, Yang MT, McLean MA, Sligar SG, Chen CS, Ha T, Schwartz MA. Grashoff C, et al. Nature. 2010 Jul 8;466(7303):263-6. doi: 10.1038/nature09198. Nature. 2010. PMID: 20613844 Free PMC article.