Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Nov;15(4):820-2.
doi: 10.1016/0272-0590(90)90198-s.

Alteration of fetal liver colony formation by prenatal chlordane exposure

J B Barnett  1 , B L Blaylock, J Gandy, J H Menna, R Denton, L S Soderberg
Affiliations

Alteration of fetal liver colony formation by prenatal chlordane exposure

J B Barnett et al. Fundam Appl Toxicol. 1990 Nov.

Abstract

Female mice were treated with 0 or 8 mg/kg chlordane daily for 18 days during pregnancy. The fetuses of these mice were assayed for fetal liver hematopoietic activity at 18 days gestational age. Hematopoietic activity was evaluated for in vitro granulocyte-macrophage colony-forming units (GM-CFU) and in vivo spleen CFU (CFU-S). The consistent finding was a significant depression of the numbers of both fetal liver GM-CFU and CFU-S without a change in liver cellularity in fetuses exposed to 8 mg/kg chlordane. These data show that the damage to stem cells that persists into adult life as a result of chlordane exposure, as reported earlier by Barnett et al. (1990) Fundam. Appl. Toxicol. 14, 688-695, occurred during the fetal period.

PubMed Disclaimer

Publication types