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Review
. 2010 Sep;36(6):611-9.
doi: 10.1055/s-0030-1262882. Epub 2010 Sep 23.

Modern determination of complement activation

Martin Oppermann  1 , Reinhard Würzner
Affiliations
Review

Modern determination of complement activation

Martin Oppermann et al. Semin Thromb Hemost. 2010 Sep.

Abstract

Modern, that is, accurate determination of complement activation in vivo requires the simultaneous determination of both naive and activated complement proteins. This is best achieved by the use of native-restricted and neoepitope-specific monoclonal antibodies in sensitive enzyme-linked immunosorbent assays. Several confounding factors also have to be taken into account to allow a correct interpretation of the results.

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