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. 2010 Dec;38(6):271-4.
doi: 10.1016/j.bioorg.2010.08.003. Epub 2010 Sep 7.

Rapid synthesis of 2',3'-dideoxy-3'β-fluoro-pyrimidine nucleosides from 2'-deoxypyrimidine nucleosides

Ahmed Khalil  1 , Christophe Mathé, Christian Périgaud
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Rapid synthesis of 2',3'-dideoxy-3'β-fluoro-pyrimidine nucleosides from 2'-deoxypyrimidine nucleosides

Ahmed Khalil et al. Bioorg Chem. 2010 Dec.

Abstract

A rapid synthesis of 2',3'-dideoxy-3'-fluoro-β-D-threo-nucleosides bearing the pyrimidine canonical bases of nucleic acids has been developed in order to discover new nucleoside derivatives as potential antiviral drugs. However, when evaluated for their antiviral activity in cell culture experiments, none of these compounds showed any significant antiviral activity.

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