Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2011 May;70(5):873-5.
doi: 10.1136/ard.2010.134155. Epub 2010 Sep 24.

The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance

Ana M Valdes, Evangelos Evangelou, Hanneke J M Kerkhof, Agu Tamm, Sally A Doherty, Kalle Kisand, Ann Tamm, Irina Kerna, Andre Uitterlinden, Albert Hofman, Fernando Rivadeneira, Cyrus Cooper, Elaine M Dennison, Weiya Zhang, Kenneth R Muir, John P A Ioannidis, Margaret Wheeler, Rose A Maciewicz, Joyce B van Meurs, Nigel K Arden, Tim D Spector, Michael Doherty
Meta-Analysis

The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance

Ana M Valdes et al. Ann Rheum Dis. 2011 May.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Competing interests RM is an Astra Zeneca plc employee and owns Astra Zeneca stock. All other authors declare no competing interests.

Figures

Figure 1
Figure 1
Forest plot of study-specific estimates and fixed-effects summary OR estimates and 95% CI for the association between the rs143383 polymorphism of the GDF5 gene and knee osteoarthritis (OA) in current and previously published studies. The summary statistics and corresponding p values for all studies and for sensitivity analyses excluding studies out of Hardy–Weinberg equilibrium (HWE; indicated by *) and/or Asian studies are shown. The between-study heterogeneity I2 and the respective 95% CI are also included.
See this image and copyright information in PMC

References

    1. Dieppe PA, Lohmander LS. Pathogenesis and management of pain in osteoarthritis. Lancet. 2005;365:965–73. - PubMed
    1. Valdes AM, Spector TD. The clinical relevance of genetic susceptibility to osteoarthritis. Best Pract Res Clin Rheumatol. 2010;24:3–14. - PubMed
    1. Mikic B. Multiple effects of GDF-5 deficiency on skeletal tissues: implications for therapeutic bioengineering. Ann Biomed Eng. 2004;32:466–76. - PubMed
    1. Miyamoto Y, Mabuchi A, Shi D, et al. A functional polymorphism in the 5′ UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat Genet. 2007;39:529–33. - PubMed
    1. Evangelou E, Chapman K, Meulenbelt I, et al. Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum. 2009;60:1710–21. - PMC - PubMed

Substances

LinkOut - more resources