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. 2010 Jun;42(3):185-8.
doi: 10.4103/0253-7613.66844.

Determination of the antiulcer properties of sodium cromoglycate in pylorus-ligated albino rats

Vivek Srivastava  1 , A H M Viswanathaswamy, Govind Mohan
Affiliations

Determination of the antiulcer properties of sodium cromoglycate in pylorus-ligated albino rats

Vivek Srivastava et al. Indian J Pharmacol. 2010 Jun.

Abstract

Objectives: To study the ulcer protective property of sodium cromoglycate in pylorusligated rats and the biochemical role in ulcer protection by various biochemical tests.

Materials and methods: The ulcer protective effect of sodium cromoglycate was studied using a Pyloric Ligation Model using Wistar albino rats. The antiulcer effect of sodium cromoglycate 40 mg/kg b.w., i.p., was compared with the reference drug ranitidine 27 mg/kg b.w., i.p. The ulcer index was calculated and other biochemical parameters like free acidity, total acidity, pH, mucin, pepsin and volume of gastric juice were determined.

Results: Pylorus ligation showed a significant (P < 0.01) reduction in gastric volume, free acidity, total acidity and ulcer index as compared to the control.

Conclusion: Sodium cromoglycate has activity equipotent to ranitidine.

Keywords: Antiulcer activity; pyloric ligation model; sodium cromoglycate; ulcer index.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Comparative antiulcer study of ranitidine and sodium cromoglycate
See this image and copyright information in PMC

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