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Review
. 2010 Sep-Oct:23 Suppl 15:S37-40.

The aging kidney: structural changes

Giovanni Pannarale  1 , Raffaella Carbone, Giuseppe Del Mastro, Carmela Gallo, Vincenzo Gattullo, Luigi Natalicchio, Antonino Navarra, Agostino Tedesco
Affiliations
  • PMID: 20872369
Review

The aging kidney: structural changes

Giovanni Pannarale et al. J Nephrol. 2010 Sep-Oct.

Abstract

A number of structural changes occur in the kidney with aging. The aging kidney is characterized by loss of renal mass, arterial sclerosis, arteriolar hyalinosis, an increased number of sclerotic glomeruli, loss of tubules and interstitial fibrosis. The pathogenesis of aging-associated structural changes is not completely understood. Both genetic background and hemodynamic factors have been associated with progression of age-related morphological changes. The structural changes of aging kidney are nonspecific and can be seen in many conditions, including diabetes and hypertension, and, as such, arterionephrosclerosis of aging is a diagnosis of exclusion.

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