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Comparative Study
. 2010;24(5):357-62.
doi: 10.1002/jcla.20415.

Evaluation of serum autoantibody levels in the diagnosis of ovarian endometrioma

Yu-Chiao Yi  1 , Shih-Chi Wang, Chun-Chin Chao, Chia-Ling Su, Yao-Ling Lee, Ling-Yun Chen
Affiliations
Comparative Study

Evaluation of serum autoantibody levels in the diagnosis of ovarian endometrioma

Yu-Chiao Yi et al. J Clin Lab Anal. 2010.

Abstract

Objective: We analyzed autoantibodies against tumor-associated antigens (TAAs) in the serum of patients with endometrioma and healthy controls to determine whether autoantibodies can be accurate biomarkers for the diagnosis of ovarian endometrioma.

Methods: Serum samples were obtained from 56 patients with endometriosis and 66 healthy women who served as normal controls. The titers of antibodies against a panel of eight TAAs were analyzed using enzyme-linked immunosorbent assay.

Results: We found that the serum IGFII mRNA-binding protein 1 (IMP1) autoantibody and cyclin B1 autoantibody could discriminate between healthy controls and endometriosis patients (AUC-ROC 0.777; 95% confidence interval [CI] 0.694-0.860, P<0.0005, and AUC-ROC 0.614; 95%confidence interval [CI] 0.513-0.714, P=0.031, respectively). Using 0.073 and 0.007 as the cutoff values for IMP1 and Cyclin B1 autoantibody, respectively, the sensitivity and specificity of IMP1 were 85.7 and 63.6%, respectively. When cylcin B1 was combined with IMP1, the specificity increased to 72.7% and the sensitivity slightly decreased to 83.9%.

Conclusions: Our data suggest that IMP1 alone or combined with cyclin B1 seems to fulfill the requirements of sensitivity and specificity to become a useful clinical biomarker of endometrioma. However, further studies will be required to establish the predictive value and to support the clinical use of IMP1/cyclin B1 in the diagnosis and/or screening of endometriosis.

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Figures

Figure 1
Figure 1
The absorbance reading of IMP1 and Cyclin B1 autoantibody in endometriosis patients and healthy controls.
Figure 2
Figure 2
Receiver operating characteristic (ROC) curves of MP1 and Cyclin B1 autoantibody for the diagnosis of ovarian endometrioma.
See this image and copyright information in PMC

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