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. 1990 Nov;29(11):1091-3.
doi: 10.1016/0028-3908(90)90118-b.

Influence of chronic chlorimipramine treatment on the serotonergic modulation of acetylcholine release from guinea pig caudate nucleus slices

A Siniscalchi  1 , L Beani, C Bianchi
Affiliations

Influence of chronic chlorimipramine treatment on the serotonergic modulation of acetylcholine release from guinea pig caudate nucleus slices

A Siniscalchi et al. Neuropharmacology. 1990 Nov.

Abstract

The influence of chronic chlorimipramine (10 mg/kg daily s.c. for 14 days) treatment (CCT) on 5-HT modulation of basal 3H-choline overflow from guinea pig caudate nucleus slices was studied. The increase in basal tritium overflow induced by 5-HT (3-100 mumol/l) or by DOI (30-100 mumol/l) in normal slices was significantly lower in CCT slices. When tetrodotoxin 0.5 mumol/l was added, the facilitatory effect by 5-HT was cancelled, its late inhibitory effect became more evident and to the same extent in normal and CCT slices. This inhibition was cancelled by ICS 205-930 30 mumol/l. These results indicate that the 5-HT2-mediated facilitatory response of intrastriatal cholinergic neurones to 5-HT is reduced by CCT, while the inhibitory response is unaffected.

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