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Multicenter Study
. 2010 Jul-Aug;44(4):613-9.

[Polymorphic markers G(-455)A of gene FGB and C(-1654)T of gene PROC and genetic predisposition to unfavorable outcomes patients undergoing acute coronary syndrome]

[Article in Russian]
Iu V Agapkina, A G Nikitin, A N Brovkin, A A Pushkov, M A Evdokimova, O Iu Kudriashova, V S Osmolovskaia, L O Minushkina, M S Kochkina, N D Selezneva, E N Dankovtseva, O S Chumakova, T N Baklanova, P A Talyzin, N E Reznichenko, O P Donetskaia, S N Tereshchenko, E S Krasil'nikova, N A Dzhaiani, E V Akatova, M G Glezer, A S Galiavich, V B Zakirova, N A Kaziolova, I V Timofeeva, A V Iagoda, O I Boeva, L I Katel'nitskaia, E V Khorolets, S V Shlyk, É G Volkova, M P Margarian, I O Guz', V O Konstantinov, A N Timofeeva, B A Sidorenko, D A Zateĭshchikiov, V V Nosikov
  • PMID: 20873219
Multicenter Study

[Polymorphic markers G(-455)A of gene FGB and C(-1654)T of gene PROC and genetic predisposition to unfavorable outcomes patients undergoing acute coronary syndrome]

[Article in Russian]
Iu V Agapkina et al. Mol Biol (Mosk). 2010 Jul-Aug.

Abstract

We investigated the association of polymorphisms of genes FGB G(-455)A and PROCC(-1654)T with coronary artery disease (CAD) in the Russian population. A total of 1145 patients with CAD diagnose on the basis of clinical studies in cardiological hospitals of Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol and Rostov-on-Don. Supervision term was 1.14 +/- +/- 0.33 years (the maximum term 3.2 years). The group studied do not differ significantly with respect to the distributions of G(-455)A alleles and genotypes. However in case of gene PROC C(-1654)T polymorphism we determined that patients with CAD diagnose and Talleles of PROC gene had unfavorable outcome more often than patients with homozygous C alleles. Survival time from end point from carrier phenotype TT and CTis 2.19 +/- 0.18 r. years against 2.46 +/- 0.16 from carrier phenotype CCgene PROC. The obtained data allows to assume the important role of the genes which are responsible for functioning of system of a hemostasis, in the accelerated formation of failures at the patients who had a coronary syndrome.

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