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Comment
. 2010 Oct 5;107(40):17069-70.
doi: 10.1073/pnas.1012748107. Epub 2010 Sep 27.

Driving a wedge between viral lipids blocks infection

Gregory B Melikyan  1
Affiliations
Comment

Driving a wedge between viral lipids blocks infection

Gregory B Melikyan. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Viral protein refolding and lipid intermediates en route to membrane fusion. (A) Viral fusion protein refolding into a stable hairpin of trimers, which is coupled to lipid rearrangement through the formation of prehairpin intermediates. (B) Progression of lipid bilayer fusion through the stalk, hemifusion, and fusion pore formation. Lipophilic compounds conferring positive curvature (red triangles) stabilize prefused membranes, preventing the stalk formation and promoting the formation of lytic pores in lipid bilayers. Lipids conferring negative curvature (yellow inverted triangles) augment hemifusion. (C) Negative curvature lipids tend to form an inverted hexagonal HII-phase, whereas positive curvature lipids assemble into micelles.
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