Comment

. 2010 Oct 5;107(40):17065-6.

doi: 10.1073/pnas.1012547107. Epub 2010 Sep 27.

Designer drugs for discerning bugs

Stephen Douthwaite¹

Affiliations

PMID: 20876111
PMCID: PMC2951416
DOI: 10.1073/pnas.1012547107

Comment

Designer drugs for discerning bugs

Stephen Douthwaite. Proc Natl Acad Sci U S A. 2010.

. 2010 Oct 5;107(40):17065-6.

doi: 10.1073/pnas.1012547107. Epub 2010 Sep 27.

Author

Stephen Douthwaite¹

Affiliation

¹ Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark.

PMID: 20876111
PMCID: PMC2951416
DOI: 10.1073/pnas.1012547107

No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

**Fig. 1.**
Secondary structure of the peptidyl transferase center in *E. coli* 23S rRNA. The site of erythromycin resistance methylation at A2058 is shown in red. Key nucleotide interactions (blue) that support antibiotic binding are the same in *T. thermophilus* but different in *H. halobium* rRNA. *D. radiodurans* rRNA has C752 (21) and thus lacks the 752–2609 bp onto which the telithromycin heterocycles would stack.

See this image and copyright information in PMC

Comment on

Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action.
Dunkle JA, Xiong L, Mankin AS, Cate JH. Dunkle JA, et al. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17152-7. doi: 10.1073/pnas.1007988107. Epub 2010 Sep 27. Proc Natl Acad Sci U S A. 2010. PMID: 20876128 Free PMC article.
Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Bulkley D, Innis CA, Blaha G, Steitz TA. Bulkley D, et al. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17158-63. doi: 10.1073/pnas.1008685107. Epub 2010 Sep 27. Proc Natl Acad Sci U S A. 2010. PMID: 20876130 Free PMC article.

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References

1. Schönfeld W, Kirst HA, editors. Macrolide Antibiotics. Basel: Birkhauser; 2002.
1. Projan SJ. Why is big Pharma getting out of antibacterial drug discovery? Curr Opin Microbiol. 2003;6:427–430. - PubMed
1. Bulkley D, et al. Revisiting the structures of several antibiotics bound to the bacterial ribosome. Proc Natl Acad Sci USA. 2010;107:17158–17163. - PMC - PubMed
1. Dunkle JA, et al. Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. Proc Natl Acad Sci USA. 2010;107:17152–17157. - PMC - PubMed
1. Wilson DN. The A-Z of bacterial translation inhibitors. Crit Rev Biochem Mol Biol. 2009;44:393–433. - PubMed

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Designer drugs for discerning bugs

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Designer drugs for discerning bugs

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