Reproducible science

doi:10.1128/IAI.00908-10

Editorial

. 2010 Dec;78(12):4972-5.

doi: 10.1128/IAI.00908-10. Epub 2010 Sep 27.

Reproducible science

Arturo Casadevall, Ferric C Fang

PMID: 20876290
PMCID: PMC2981311
DOI: 10.1128/IAI.00908-10

Editorial

Reproducible science

Arturo Casadevall et al. Infect Immun. 2010 Dec.

. 2010 Dec;78(12):4972-5.

doi: 10.1128/IAI.00908-10. Epub 2010 Sep 27.

Authors

Arturo Casadevall, Ferric C Fang

PMID: 20876290
PMCID: PMC2981311
DOI: 10.1128/IAI.00908-10

Abstract

The reproducibility of an experimental result is a fundamental assumption in science. Yet, results that are merely confirmatory of previous findings are given low priority and can be difficult to publish. Furthermore, the complex and chaotic nature of biological systems imposes limitations on the replicability of scientific experiments. This essay explores the importance and limits of reproducibility in scientific manuscripts.

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References

1. American Physical Society. 2000. First experiment to draw electricity from lightning, May 10, 1752. APS News 9:6.
1. Barnes, P. D., M. A. Bergman, J. Mecsas, and R. R. Isberg. 2006. Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine. J. Exp. Med. 203:1591-1601. - PMC - PubMed
1. Bernal, S. K. 2006. A massive snowball of fraud and deceit. J. Androl. 27:313-315. - PubMed
1. Blount, Z. D., C. Z. Borland, and R. E. Lenski. 2008. Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 105:7899-7906. - PMC - PubMed
1. Buck, M. J., and J. D. Lieb. 2004. ChIP-chip: considerations for the design, analysis, and application of genome-wide chromatin immunoprecipitation experiments. Genomics 83:349-360. - PubMed

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[1] American Physical Society. 2000. First experiment to draw electricity from lightning, May 10, 1752. APS News 9:6.

[2] American Physical Society. 2000. First experiment to draw electricity from lightning, May 10, 1752. APS News 9:6.

[3] Barnes, P. D., M. A. Bergman, J. Mecsas, and R. R. Isberg. 2006. Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine. J. Exp. Med. 203:1591-1601. - PMC - PubMed

[4] Barnes, P. D., M. A. Bergman, J. Mecsas, and R. R. Isberg. 2006. Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine. J. Exp. Med. 203:1591-1601. - PMC - PubMed

[5] Bernal, S. K. 2006. A massive snowball of fraud and deceit. J. Androl. 27:313-315. - PubMed

[6] Bernal, S. K. 2006. A massive snowball of fraud and deceit. J. Androl. 27:313-315. - PubMed

[7] Blount, Z. D., C. Z. Borland, and R. E. Lenski. 2008. Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 105:7899-7906. - PMC - PubMed

[8] Blount, Z. D., C. Z. Borland, and R. E. Lenski. 2008. Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 105:7899-7906. - PMC - PubMed

[9] Buck, M. J., and J. D. Lieb. 2004. ChIP-chip: considerations for the design, analysis, and application of genome-wide chromatin immunoprecipitation experiments. Genomics 83:349-360. - PubMed

[10] Buck, M. J., and J. D. Lieb. 2004. ChIP-chip: considerations for the design, analysis, and application of genome-wide chromatin immunoprecipitation experiments. Genomics 83:349-360. - PubMed

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Reproducible science

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