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Review
. 2010 Oct;59(10):2340-8.
doi: 10.2337/db10-0084.

Beta-cell growth and regeneration: replication is only part of the story

Susan Bonner-Weir  1 , Wan-Chun Li, Limor Ouziel-Yahalom, Lili Guo, Gordon C Weir, Arun Sharma
Affiliations
Review

Beta-cell growth and regeneration: replication is only part of the story

Susan Bonner-Weir et al. Diabetes. 2010 Oct.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Neogenesis in mouse pancreas. A: The metaplastic ducts seen in the zinc-treated metallothionen. TGF-α transgenic mice have 6% insulin+ (red, white arrows) cells and some amylase+ (green, yellow arrow) cells. Tissue from study reported in (37); the background in the red channel was enhanced to see the context of the ducts. Magnification bar = 100 μm. B: After partial (70–80%) pancreatectomy in adult mice, insulin+ (blue) cells “budding” from proliferating ductules labeled with E-cadherin (red) are found in well-defined areas termed foci of regeneration that further differentiate into new lobes of pancreas (40). Magnification bar = 50 μm. (A high-quality digital representation of this figure is available in the online issue.)
FIG. 2.
FIG. 2.
Neogenesis in adult human pancreas. Insulin+ (brown) cells seen in the ducts in adult human pancreas. A: Surgical sample from patient who had partial pancreatectomy due to recurrent postprandial hypoglycemia after gastric bypass as reported in Patti et al. (79). While no Ki67+ islet cells were seen in sections from this pancreas, many ductal cells were Ki67+ (not shown) and many insulin+ cells are seen within the ductules. Magnification bar = 100 μm. B: Insulin+ cells are found within the ductal epithelium in human pancreas. Magnification bar = 20 um. (A high-quality digital representation of this figure is available in the online issue.)
See this image and copyright information in PMC

References

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    1. Finegood DT, Scaglia L, Bonner-Weir S. Dynamics of β-cell mass in the growing rat pancreas: estimation with a simple mathematical model. Diabetes 1995;44:249–256 - PubMed

Publication types