Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Sep;89(3):301-5.
doi: 10.1007/s12041-010-0041-y.

Use of a regulatory mechanism of sex determination in pest insect control

Tarig Dafa'alla  1 , Guoliang Fu, Luke Alphey
Affiliations

Use of a regulatory mechanism of sex determination in pest insect control

Tarig Dafa'alla et al. J Genet. 2010 Sep.

Abstract

The sexual development of an insect is defined through a hierarchical control of several sex determining genes. Of these genes, transformer (tra) and doublesex (dsx) are well characterized and functionally conserved, especially dsx. Both genes are regulated at the transcriptional level through sex-specific alternative splicing. Incorporation of a genetically engineered sexspecific splicing module derived from these genes in transgenic systems, such as RIDL (release of insects carrying a dominant lethal), would allow the production of male-only insects for control programmes without any physical intervention.

PubMed Disclaimer

References

    1. Development. 1998 Apr;125(8):1487-94 - PubMed
    1. Genetics. 1992 May;131(1):113-28 - PubMed
    1. Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4550-4 - PubMed
    1. Genetics. 1996 Oct;144(2):737-45 - PubMed
    1. Nat Biotechnol. 2005 Apr;23(4):453-6 - PubMed

LinkOut - more resources