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Comment
. 2010 Oct;120(10):3437-40.
doi: 10.1172/JCI44721. Epub 2010 Sep 27.

In obesity and weight loss, all roads lead to the mighty macrophage

Alex Red Eagle  1 , Ajay Chawla
Affiliations
Comment

In obesity and weight loss, all roads lead to the mighty macrophage

Alex Red Eagle et al. J Clin Invest. 2010 Oct.

Abstract

Obesity is associated with infiltration of white adipose tissue (WAT) by macrophages, which contributes to the development of insulin resistance. In this issue of the JCI, Kosteli and colleagues demonstrate that weight loss is unexpectedly also associated with rapid, albeit transient, recruitment of macrophages to WAT and that this appears to be related to lipolysis.

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Figures

Figure 1
Figure 1. WAT macrophage content and adipose tissue lipolysis.
(A) Adipose tissue contains a resident pool of macrophages (F4/80+CD11c–CD301+). Obesity leads to the recruitment of inflammatory (F4/80+CD11c+CD301–) macrophages, which are associated with insulin resistance. Early weight loss and fasting lead to the recruitment of an unexplored population of “antiinflammatory” macrophages (F4/80+CD11c–). (B) The recruitment of this novel population correlates with release of FFAs and regulates adipose tissue lipolysis.
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References

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