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. 2010 Sep 28;103(7):1128-35.
doi: 10.1038/sj.bjc.6605838.

Pooled analysis of recent studies on magnetic fields and childhood leukaemia

L Kheifets  1 , A Ahlbom, C M Crespi, G Draper, J Hagihara, R M Lowenthal, G Mezei, S Oksuzyan, J Schüz, J Swanson, A Tittarelli, M Vinceti, V Wunsch Filho
Affiliations

Pooled analysis of recent studies on magnetic fields and childhood leukaemia

L Kheifets et al. Br J Cancer. .

Erratum in

  • Br J Cancer. 2011 Jan 4;104(1):228

Abstract

Background: Previous pooled analyses have reported an association between magnetic fields and childhood leukaemia. We present a pooled analysis based on primary data from studies on residential magnetic fields and childhood leukaemia published after 2000.

Methods: Seven studies with a total of 10,865 cases and 12,853 controls were included. The main analysis focused on 24-h magnetic field measurements or calculated fields in residences.

Results: In the combined results, risk increased with increase in exposure, but the estimates were imprecise. The odds ratios for exposure categories of 0.1-0.2 μT, 0.2-0.3 μT and ≥0.3 μT, compared with <0.1 μT, were 1.07 (95% CI 0.81-1.41), 1.16 (0.69-1.93) and 1.44 (0.88-2.36), respectively. Without the most influential study from Brazil, the odds ratios increased somewhat. An increasing trend was also suggested by a nonparametric analysis conducted using a generalised additive model.

Conclusions: Our results are in line with previous pooled analyses showing an association between magnetic fields and childhood leukaemia. Overall, the association is weaker in the most recently conducted studies, but these studies are small and lack methodological improvements needed to resolve the apparent association. We conclude that recent studies on magnetic fields and childhood leukaemia do not alter the previous assessment that magnetic fields are possibly carcinogenic.

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Figures

Figure 1
Figure 1
Odds ratios (95% CI) for moving window of exposure levels, adjusted for age, sex, SES and study. Reference level: <0.1 μT.
Figure 2
Figure 2
Nonparametric estimates of trend in log odds of being a case with a range of levels of smoothing (A. 2 d.f.; B. 3 d.f.; C. 4 d.f.; D. 5 d.f.) from a generalised additive model, with adjustment for study, age of diagnosis and sex. Outer dotted lines represent 95% confidence limits.
See this image and copyright information in PMC

Comment in

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