Oncotype DX tumor gene expression profiling in stage II colon cancer. Application: prognostic, risk prediction
- PMID: 20877447
- PMCID: PMC2940137
- DOI: 10.1371/currents.RRN1177
Oncotype DX tumor gene expression profiling in stage II colon cancer. Application: prognostic, risk prediction
Abstract
Overall five-year survival for patients with stage-II colon cancer averages 75% after surgery alone. However, some of these patients have poorer outcomes, similar to patients with stage-III disease. The proposed use of the Oncotype DX assay is to improve risk stratification for recurrence in stage-II colon cancer.
References
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- Lavery I, Hammel J, Cowens J, et al. Relationship between tumor gene expression and recurrence in an observational cohort of patients with stage II/III colon cancer treated with surgery only: Quantitative RT-PCR assay of 375 genes in fixed paraffin-embedded (FPE) tissue. Presented at: American Society of Clinical Oncology 2008 Gastrointestinal Cancers Symposium; January 25-27, 2008; Orlando, FL. Abstract 302.
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- O’Connell MJ, Lavery IC, Gray RG et al Comparison of molecular and pathologic features of stage II and stage III colon cancer in four large studies conducted for development of the 12-gene colon cancer recurrence score. American Society of Clinical Oncology gastrointestinal Cancers Symposium, 2010, Abstract 280.
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