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. 2010 Sep 2:2:RRN1175.
doi: 10.1371/currents.RRN1175.

KRAS mutational analysis for colorectal cancer. Application: pharmacogenomic

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KRAS mutational analysis for colorectal cancer. Application: pharmacogenomic

Grace Wang et al. PLoS Curr. .

Abstract

KRAS mutational analysis is a genetic test used in clinical practice for determining the status of the KRAS gene (wild type or mutant) in tumors from patients with metastatic colorectal cancer (CRC). Persons whose tumors are wild type may respond to therapies cetuximab (Erbitux) or panitumumab (Vectibix).

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References

    1. Normanno, N., et al., Implications for KRAS status and EGFR-targeted therapies in metastatic CRC. Nat Rev Clin Oncol, 2009. 6(9): p. 519-27. - PubMed
    1. KRAS mutations and epidermal growth factor receptor inhibitor therapy in metastatic colorectal cancer. Technol Eval Cent Asses Program Exec Summ, 2009. 23(6): p. 1-3. - PubMed
    1. National Cancer Institute. SEER Stat Fact Sheets: Colon and Rectum. 2010 [cited 2010 April 26];http://seer.cancer.gov/statfacts/html/colorect.html
    1. NCCN Updates Guidelines for Colorectal Cancer ; NCCN announces new updates to the NCCN Guidelines for Colon and Rectal Cancers . The updates include recommendations to the pre-treatment work-up and use of anti- cancer agents in patients with metastatic colorectal cancer depending on the status of the tumor's KRAS gene. The changes are based on recent studies demonstrating that the tumor KRAS gene status is highly predictive of outcome with certain therapies, in Business Wire. 2008.
    1. National Comprehensive Cancer Network. Colon Cancer. NCCN Clinical Practice Guidelines in Oncology 2009 [cited 2009 October 21];http://www.nccn.org/professionals/physician_gls/PDF/colon.pdf