Mineral Oil-induced Sclerosing Lipogranuloma of the Penis

Abstract

Sclerosing lipogranuloma of the penis results from injection of high viscosity fluid for the purpose of penile augmentation and may have devastating cosmetic and sexual function consequences. Although rare, sclerosing lipogranuloma should be considered in the differential diagnosis of subcutaneous induration or nodules of the male genitalia as it may mimic carcinoma and poses a diagnostic challenge in patients reluctant to admit to injection therapy. Surgical excision with penile reconstruction is the mainstay of treatment. The authors present a case of a 35-year-old Myanmarese man with a sclerosing lipogranuloma of the penis due to injection of mineral oil successfully managed with penile biopsy and excision with split-thickness skin graft phalloplasty and provide a review of the current literature.

Figure 1

Sclerosing lipogranuloma of the penis (A); after excision of the suprapubic, penile, and penoscrotal indurated cutaneous and subcutaneous skin (B); with split thickness skin graft phalloplasty (C).

Figure 1

Hematoxylin and eosin, 40X magnification. Thickened reticular dermis with replacement of normal subcutaneous fat by lakes of oil interspersed in foreign body giant cells.