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Case Reports
. 2010 Aug;3(8):34-5.

A Second Case of Sunitinib-associated Pyoderma Gangrenosum

Steven M Dean  1 , Matthew Zirwas
Affiliations
Case Reports

A Second Case of Sunitinib-associated Pyoderma Gangrenosum

Steven M Dean et al. J Clin Aesthet Dermatol. 2010 Aug.

Abstract

Pyoderma gangrenosum is a painful, noninfectious, ulcerative, cutaneous disorder that most commonly affects the lower extremities. The diagnosis is made by recognizing the characteristic clinical manifestations in the setting of a causative systemic disease and excluding other causes of similar-appearing ulcerations. Pyoderma gangrenosum often evolves in the setting of systemic illnesses, such as inflammatory bowel disease, rheumatological disorders, and hematological conditions. However, several medications have rarely been linked to pyoderma gangrenosum. The authors report the second case of sunitinib-associated pyoderma gangrenosum in a 61-year-old patient with recurrent renal cell carcinoma.

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Figures

Figure 1
Figure 1
Painful, deep 4.9 × 4.5cm distal lateral calf pyoderma gangrenosum ulceration with a fibropurulent base and violaceous, partially necrotic border
Figure 2
Figure 2
Sixteen weeks after termination of sunitinib, the calf ulceration healed.
See this image and copyright information in PMC

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