Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2009;4(1):36-38.
doi: 10.1159/000190078. Epub 2009 Feb 20.

Invasive Lobular Carcinoma of the Male Breast: A Rare Histology in an Uncommon Disease

Susanne Briest  1 , Russell Vang, Kyle Terrell, Leisha Emens, Julie R Lange
Affiliations
Case Reports

Invasive Lobular Carcinoma of the Male Breast: A Rare Histology in an Uncommon Disease

Susanne Briest et al. Breast Care (Basel). 2009.

Abstract
in English, German

SUMMARY: BACKGROUND: Breast cancer in men is an uncommon disease. Nearly all cases of male breast cancer originate in the terminal ductulolobular unit, with exceedingly rare reports of lobular carcinoma in men. Invasive lobular cancer is found in no more than 1-2% of male breast cancer cases. Most of what is known about this disease is in the form of approximately 30 case reports in the literature. CASE REPORT: We report the case of a 52-year-old man who presented at our institution with a lump in his left breast. Ultrasound-guided biopsy revealed an invasive lobular cancer. The rare histological type was confirmed by the result of the histological examination of the mastectomy specimen. The treatment was completed by dose dense chemotherapy, radiation, and endocrine therapy. CONCLUSION: Even though lobular structures are quite infrequent in the normal male, sporadic cases of invasive lobular breast cancer have been described. A short overview will be given in this case report.

Hintergrund: Brustkrebs ist eine ungewöhnliche Erkrankung beim Mann. Nahezu alle Erkrankungen leiten sich histopathologisch von der terminalen duktulolobulären Einheit der Brustdrüse ab. Das invasiv lobuläre Karzinom ist äußerst selten und ist nur in 1-2% der Fälle beim Mammakarzinom des Mannes beschrieben. Die Erkenntnisse rühren von zirka 30 publizierten Kasuistiken her.

Fallbericht: In unserer Einrichtung stellte sich ein 52-jähriger Mann mit einem Tastbefund in der linken Brust vor. Die sonografisch gestützte Stanzbiopsie ergab das Vorliegen eines invasiv lobulären Mammakarzinoms. Der seltene histopathologische Befund wurde bei der Untersuchung des Mastektomiepräparates bestätigt. Die Behandlung des Patienten wurde vervollständigt durch eine dosisdichte Chemotherapie, Bestrahlung und endokrine Behandlung.

Schlussfolgerung: Obwohl lobuläre Strukturen in der Brustdrüse des Mannes seltener und wesentlich kleiner sind, ist das sporadische Auftreten des invasiv lobulären Mammakarzinoms beim Mann beschrieben worden. In diesem Artikel soll ein kurzer Überblick darüber gegeben werden.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
H&E histological section of the breast tumor showing invasive lobular carcinoma. A classic individual cell filing pattern is present.
See this image and copyright information in PMC

References

    1. Giordano SH, Cohen DS, Buzdar AU, Perkins G, Hortobagyi GN. Breast carcinoma in men: a population-based study. Cancer. 2004;101:51–57. - PubMed
    1. Nahleh ZA, Srikantiah R, Safa M, Jazieh AR, Muhleman A, Komrokji R. Male breast cancer in the veterans affairs population: a comparative analysis. Cancer. 2007;109:1471–1477. - PubMed
    1. Agrawal A, Ayantunde AA, Rampaul R, Robertson JF. Male breast cancer: a review of clinical management. Breast Cancer Res Treat. 2007;103:11–21. - PubMed
    1. Goss PE, Reid C, Pintilie M, Lim R, Miller N. Male breast carcinoma: a review of 229 patients who presented to the Princess Margaret Hospital during 40 years: 1955-1996. Cancer. 1999;85:629–639. - PubMed
    1. Rudlowski C. Male breast cancer. Breast Care. 2008;3:183–189. - PMC - PubMed

Publication types