Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Oct;25(5):440-3.
doi: 10.1590/s0102-86502010000500010.

Capsaicin on the viability of random-pattern skin flaps in rats

Gustavo Roberto de Godoy  1 , Richard Eloin Liebano, Juliana Barbosa Corrêa, Bernardo Hochman, Lydia Masako Ferreira
Affiliations
Free article

Capsaicin on the viability of random-pattern skin flaps in rats

Gustavo Roberto de Godoy et al. Acta Cir Bras. 2010 Oct.
Free article

Abstract

Purpose: To evaluate the effects of capsaicin on the viability of ischemic random-pattern skin flaps in rats.

Methods: Forty EPM1-Wistar rats were randomized into two groups of 20 animals each, the capsaicin group and the control group. A random-pattern skin flap measuring 10 x 4 cm was raised and a plastic barrier was placed between the flap and the donor site. After the surgical procedure, the control group was treated with an inert vehicle in the form of a cream applied uniformly to a rayon bandage which, in turn, was applied to the surface of the skin flap. The capsaicin group was treated in the same way, but in this case capsaicin was added to the cream. This procedure was repeated for two consecutive days.

Results: There was a significantly smaller amount of flap necrosis in the capsaicin group (35.07%) than in the control group (44.75%) (p=0.035).

Conclusion: Topical administration of capsaicin improved the viability of ischemic random-pattern skin flaps in rats.

PubMed Disclaimer

Publication types

LinkOut - more resources