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Randomized Controlled Trial
. 2011 Feb;41(1):119-30.
doi: 10.1007/s12160-010-9232-2.

A randomized controlled trial of behavioral weight loss treatment versus combined weight loss/depression treatment among women with comorbid obesity and depression

Jennifer A Linde  1 , Gregory E Simon, Evette J Ludman, Laura E Ichikawa, Belinda H Operskalski, David Arterburn, Paul Rohde, Emily A Finch, Robert W Jeffery
Affiliations
Randomized Controlled Trial

A randomized controlled trial of behavioral weight loss treatment versus combined weight loss/depression treatment among women with comorbid obesity and depression

Jennifer A Linde et al. Ann Behav Med. 2011 Feb.

Abstract

Background: Obesity is associated with clinical depression among women. However, depressed women are often excluded from weight loss trials.

Purpose: This study examined treatment outcomes among women with comorbid obesity and depression.

Methods: Two hundred three (203) women were randomized to behavioral weight loss (n = 102) or behavioral weight loss combined with cognitive-behavioral depression management (n = 101).

Results: Average participant age was 52 years; mean baseline body mass index was 39 kg/m(2). Mean Patient Health Questionnaire and Hopkins Symptom Checklist (SCL-20) scores indicated moderate to severe baseline depression. Weight loss and SCL-20 changes did not differ between groups at 6 or 12 months in intent-to-treat analyses (p = 0.26 and 0.55 for weight, p = 0.70 and 0.25 for depressive symptoms).

Conclusions: Depressed obese women lost weight and demonstrated improved mood in both treatment programs. Future weight loss trials are encouraged to enroll depressed women.

Trial registration: ClinicalTrials.gov NCT00169273.

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Conflict of interest statement

Conflict of Interest Statement The authors have no conflicts of interest to disclose.

Figures

Fig. 1
Fig. 1
Study recruitment flow diagram
Fig. 2
Fig. 2
a Means and standard errors of weight change (in kilograms) over time by treatment session attendance. b Means and standard errors of depressive symptom change over time by treatment session attendance
Fig. 3
Fig. 3
a Means and standard errors of dietary intake changes by treatment group. b Means and standard errors of physical activity changes by treatment group
See this image and copyright information in PMC

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