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. 2011 Feb;258(2):302-7.
doi: 10.1007/s00415-010-5756-4. Epub 2010 Sep 30.

An early rise in body temperature is related to unfavorable outcome after stroke: data from the PAIS study

Heleen M den Hertog  1 , H Bart van der Worp, H Maarten A van Gemert, Ale Algra, L Jaap Kappelle, Jan van Gijn, Peter J Koudstaal, Diederik W J Dippel
Affiliations

An early rise in body temperature is related to unfavorable outcome after stroke: data from the PAIS study

Heleen M den Hertog et al. J Neurol. 2011 Feb.

Abstract

Subfebrile temperature or fever is present in about a third of patients on the first day after stroke onset and is associated with poor outcome. However, the temporal profile of this association is not well established. We aimed to assess the relationship between body temperature on admission as well as the change in body temperature from admission to 24 h thereafter and functional outcome and death. We analyzed data of 1,332 patients admitted within 12 h of stroke onset. The relation between body temperature on admission or the change in body temperature from admission to 24 h thereafter (adjusted for body temperature on admission) on the one hand and unfavorable outcome (death, or a modified Rankin Scale score >2) at 3 months on the other were expressed as odds ratio per 1.0°C increase in body temperature. Adjustments for potential confounders were made with a multiple logistic regression model. No relation was found between admission body temperature and poor outcome (aOR 1.06; 95% CI 0.85-1.32) and death (aOR 1.23; 95% CI 0.95-1.60). In contrast, increased body temperature in the first 24 h after stroke onset was associated with poor outcome (aOR 1.30; 95% CI 1.05-1.63) and death (aOR 1.51; 95% CI 1.15-1.98). An early rise in body temperature rather than high body temperature on admission is a risk factor for unfavorable outcome in patients with acute stroke.

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Figures

Fig. 1
Fig. 1
The change in body temperature in the first 24 h from admission to 24 h thereafter (ºC) as a function of body temperature on admission (ºC)
Fig. 2
Fig. 2
Stroke severity (quartiles) and body temperature within 12 h from stroke onset, (grey bars) and 24 h later (black bars)
Fig. 3
Fig. 3
Probability of poor outcome (mRS >2) at 3 months in relation to change in body temperature from baseline to 24 h thereafter (sixtiles) (ºC)
See this image and copyright information in PMC

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