doi: 10.1128/AAC.34.12.2426.
Activity of cefixime against Helicobacter pylori and affinities for the penicillin-binding proteins
Affiliations
- PMID: 2088199
- PMCID: PMC172075
- DOI: 10.1128/AAC.34.12.2426
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Activity of cefixime against Helicobacter pylori and affinities for the penicillin-binding proteins
Antimicrob Agents Chemother.
1990 Dec.
Abstract
Cefixime induced the formation of rounded cells from the spiral bacillary form of Helicobacter pylori at the MIC or less. Three main penicillin-binding proteins, called A, B and C, were separated from H. pylori. Cefixime had the strongest affinity to penicillin-binding protein B. The binding of cefixime to this protein may induce the formation of rounded H. pylori cells.
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