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. 1990 Dec;34(12):2439-41.
doi: 10.1128/AAC.34.12.2439.

Nucleotide sequence of the SHV-5 beta-lactamase gene of a Klebsiella pneumoniae plasmid

D Billot-Klein  1 , L Gutmann, E Collatz
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Nucleotide sequence of the SHV-5 beta-lactamase gene of a Klebsiella pneumoniae plasmid

D Billot-Klein et al. Antimicrob Agents Chemother. 1990 Dec.

Abstract

The nucleotide sequence of the SHV-5 beta-lactamase gene, subcloned from a plasmid of Klebsiella pneumoniae, was determined. The amino acid changes thought to be responsible for the extended substrate profile of SHV-5 are Gly----Ser234 and Glu----Lys235. SHV-5 is identical to SHV-4, except for Leu----Arg201, which accounts for the difference in apparent pI of the two enzymes.

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References

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