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. 2010 Sep;17 Suppl 2(Suppl 2):S55-64.
doi: 10.3747/co.v17i0.709.

Cardiac and cognitive effects of androgen deprivation therapy: are they real?

S M H Alibhai  1 , H Z Mohamedali
Affiliations

Cardiac and cognitive effects of androgen deprivation therapy: are they real?

S M H Alibhai et al. Curr Oncol. 2010 Sep.

Abstract

With androgen deprivation therapy being used ever earlier and longer in the course of prostate cancer, concerns have emerged about a variety of adverse effects, including cardiovascular disease and cognitive dysfunction. Conflicting data in both areas have led to controversy and confusion. Here, we review published data in an attempt to clarify those issues.

Keywords: Prostatic neoplasms; adverse effects; androgen deprivation therapy; cardiac disease; cognition.

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References

    1. Huggins C, Hodges CV. The effect of castration and estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate. CA Cancer J Clin. 1972;22:232–40. - PubMed
    1. Keating NL, O’Malley AJ, Freedland SJ, Smith MR. Diabetes and cardiovascular disease during androgen deprivation therapy: observational study of veterans with prostate cancer. J Natl Cancer Inst. 2010;102:39–46. - PMC - PubMed
    1. Meng MV, Grossfeld GD, Sadetsky N, Mehta SS, Lubeck DP, Carroll PR. Contemporary patterns of androgen deprivation therapy use for newly diagnosed prostate cancer. Urology. 2002;60(suppl 1):7–11. - PubMed
    1. Levine GN, D’Amico AV, Berger P, et al. Androgen-deprivation therapy in prostate cancer and cardiovascular risk: a science advisory from the American Heart Association, American Cancer Society, and American Urological Association: endorsed by the American Society for Radiation Oncology. Circulation. 2010;121:833–40. - PMC - PubMed
    1. Nelson CJ, Lee JS, Gamboa MC, Roth AJ. Cognitive effects of hormone therapy in men with prostate cancer: a review. Cancer. 2008;113:1097–106. - PMC - PubMed

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