doi: 10.4103/0019-5049.68383.
Antitubercular drug poisoning in a pregnant woman
Affiliations
- PMID: 20882178
- PMCID: PMC2943705
- DOI: 10.4103/0019-5049.68383
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Antitubercular drug poisoning in a pregnant woman
Indian J Anaesth.
2010 Jul.
Abstract
A 20-year-old female in her third month of pregnancy, presented with generalised tonic clonic seizures, metabolic acidosis and coma following suicidal ingestion of antitubercular medication. We successfully managed the case with pyridoxine, sodium bicarbonate and mechanical ventilation.
Keywords: Acute-intoxication; antitubercular; pregnancy; pyridoxine.
Conflict of interest statement
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References
-
- Vasu T, Saluja J. INH induced status epilepticus: Response to pyridoxine. Indian J Chest Dis Allied Sci. 2006;48:205–6. - PubMed
-
- Shannon MW, Lovejoy FH., Jr . Isoniazid. In: Haddad LM, Winchester JF, editors. Clinical Management of Poisoning and Drug Overdose. 2nd ed. Philadelphia, PA: Saunders; 1990. pp. 970–5.
-
- Temmerman W, Dhondt A, Vandewoude K. Acute isoniazid intoxication: Seziure, acidosis and coma. Acta Clin Belg. 1999;54:211–6. - PubMed
-
- Wood JD, Preesker S. A correlation between changes in GABA metabolism and nicotinic acid hydrazide-induced seizures. Brain Res. 1972;45:489–98. - PubMed
-
- Carey RE, Wood JD. Isonicotinic acid hydrazide-induced changes in the metabolism of γ-aminobutyric acid in the brain of four species. Camp Biochem Pysiol. 1973;45:741–848. - PubMed
