From Freud to a modern understanding of behavioral, physiological, and brain development
- PMID: 20882587
- PMCID: PMC4821214
- DOI: 10.1002/dev.20496
From Freud to a modern understanding of behavioral, physiological, and brain development
Abstract
Seymour Levine's first "early experience" experiments were inspired by Freud. Yet, Levine's lifetime of work, and the work of his colleagues and scientists who followed, unveiled a myriad of early experience effects that even Freud himself could not have imagined. Related to and extending beyond his work on early experience, Levine also made important, often seminal, contributions to overlapping and related areas, such as early maternal separation and deprivation, maternal behavior and physiology, sexual differentiation, perinatal malnutrition, attachment in non-human primates, hypothalamic-pituitary-adrenal (HPA) stress reactivity and its adaptive significance, and the development of the HPA system. Moreover, his work spawned new lines of research by investigators active today. The papers contained in this special issue provide a sampling of research demonstrating some of the important directions in which those earliest experiments have led, many with clinical applications.
© 2010 Wiley Periodicals, Inc.
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References
-
- Ader R, Friedman SB. Social factors affecting emotionality and resistance to disease in animals. V. Early separation from the mother and response to transplanted tumor in the rat. Psychosomatic Medicine. 1965;7:119–122. - PubMed
-
- Brown CP, Smotherman WP, Levine S. Interaction-induced reduction in differential maternal responsiveness: An effect of cue-reduction or behavior? Developmental Psychobiology. 1977;10:273–280. - PubMed
-
- Cirulli F, Suchecki D Guest Editors. Developmental determinants of sensitivity and resistance to stress: A tribute to Seymour “Gig” Levine. Neuroscience and Biobehavioral Reviews. 2010;34(6):781. - PubMed
-
- Coe CL, Glass JC, Wiener SG, Levine S. Behavioral, but not physiological, adaptation to repeated separation in mother and infant primates. Psychoneuroendocrinology. 1983;8:401–409. - PubMed
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