Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2010 Oct 5;56(15):1196-204.
doi: 10.1016/j.jacc.2010.02.075.

Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (controlled rosuvastatin multinational study in heart failure)

John J V McMurray  1 , Peter Dunselman, Hans Wedel, John G F Cleland, Magnus Lindberg, Ake Hjalmarson, John Kjekshus, Finn Waagstein, Eduard Apetrei, Vivencio Barrios, Michael Böhm, Gabriel Kamenský, Michel Komajda, Vyacheslav Mareev, John Wikstrand; CORONA Study Group
Affiliations
Free article
Randomized Controlled Trial

Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (controlled rosuvastatin multinational study in heart failure)

John J V McMurray et al. J Am Coll Cardiol. .
Free article

Abstract

Objectives: The purpose of this study was to determine whether coenzyme Q₁₀ is an independent predictor of prognosis in heart failure.

Background: Blood and tissue concentrations of the essential cofactor coenzyme Q₁₀ are decreased by statins, and this could be harmful in patients with heart failure.

Methods: We measured serum coenzyme Q₁₀ in 1,191 patients with ischemic systolic heart failure enrolled in CORONA (Controlled Rosuvastatin Multinational Study in Heart Failure) and related this to clinical outcomes.

Results: Patients with lower coenzyme Q₁₀ concentrations were older and had more advanced heart failure. Mortality was significantly higher among patients in the lowest compared to the highest coenzyme Q₁₀ tertile in a univariate analysis (hazard ratio: 1.50, 95% confidence interval: 1.04 to 2.6, p = 0.03) but not in a multivariable analysis. Coenzyme Q₁₀ was not an independent predictor of any other clinical outcome. Rosuvastatin reduced coenzyme Q₁₀ but there was no interaction between coenzyme Q₁₀ and the effect of rosuvastatin.

Conclusions: Coenzyme Q₁₀ is not an independent prognostic variable in heart failure. Rosuvastatin reduced coenzyme Q₁₀, but even in patients with a low baseline coenzyme Q₁₀, rosuvastatin treatment was not associated with a significantly worse outcome. (Controlled Rosuvastatin Multinational Study in Heart Failure [CORONA]; NCT00206310).

PubMed Disclaimer

Comment in

Similar articles

See all similar articles

Cited by

  • Micronutrient deficiencies in heart failure: Mitochondrial dysfunction as a common pathophysiological mechanism?
    Bomer N, Pavez-Giani MG, Grote Beverborg N, Cleland JGF, van Veldhuisen DJ, van der Meer P. Bomer N, et al. J Intern Med. 2022 Jun;291(6):713-731. doi: 10.1111/joim.13456. Epub 2022 Feb 9. J Intern Med. 2022. PMID: 35137472 Free PMC article. Review.
  • Heart Failure-Do We Need New Drugs or Have Them Already? A Case of Coenzyme Q10.
    Filipiak KJ, Surma S, Romańczyk M, Okopień B. Filipiak KJ, et al. J Cardiovasc Dev Dis. 2022 May 16;9(5):161. doi: 10.3390/jcdd9050161. J Cardiovasc Dev Dis. 2022. PMID: 35621872 Free PMC article. Review.
  • Effects of Statin Therapy on Clinical Outcomes of Survivors of Acute Myocardial Infarction with Severe Systolic Heart Failure.
    Woo JS, Hwang SJ, Kim HS, Kim JB, Kim WS, Kim KS, Jeong MH, Kim W; Korea Acute Myocardial Infarction Registry Investigators. Woo JS, et al. PLoS One. 2015 Dec 11;10(12):e0144602. doi: 10.1371/journal.pone.0144602. eCollection 2015. PLoS One. 2015. PMID: 26658751 Free PMC article.
  • CSI position statement on management of heart failure in India.
    Guha S, Harikrishnan S, Ray S, Sethi R, Ramakrishnan S, Banerjee S, Bahl VK, Goswami KC, Banerjee AK, Shanmugasundaram S, Kerkar PG, Seth S, Yadav R, Kapoor A, Mahajan AU, Mohanan PP, Mishra S, Deb PK, Narasimhan C, Pancholia AK, Sinha A, Pradhan A, Alagesan R, Roy A, Vora A, Saxena A, Dasbiswas A, Srinivas BC, Chattopadhyay BP, Singh BP, Balachandar J, Balakrishnan KR, Pinto B, Manjunath CN, Lanjewar CP, Jain D, Sarma D, Paul GJ, Zachariah GA, Chopra HK, Vijayalakshmi IB, Tharakan JA, Dalal JJ, Sawhney JPS, Saha J, Christopher J, Talwar KK, Chandra KS, Venugopal K, Ganguly K, Hiremath MS, Hot M, Das MK, Bardolui N, Deshpande NV, Yadava OP, Bhardwaj P, Vishwakarma P, Rajput RK, Gupta R, Somasundaram S, Routray SN, Iyengar SS, Sanjay G, Tewari S, G S, Kumar S, Mookerjee S, Nair T, Mishra T, Samal UC, Kaul U, Chopra VK, Narain VS, Raj V, Lokhandwala Y. Guha S, et al. Indian Heart J. 2018 Jul;70 Suppl 1(Suppl 1):S1-S72. doi: 10.1016/j.ihj.2018.05.003. Epub 2018 Jun 8. Indian Heart J. 2018. PMID: 30122238 Free PMC article. Review. No abstract available.
  • Critical illness is associated with decreased plasma levels of coenzyme Q10: a cross-sectional study.
    Coppadoro A, Berra L, Kumar A, Pinciroli R, Yamada M, Schmidt UH, Bittner EA, Kaneki M. Coppadoro A, et al. J Crit Care. 2013 Oct;28(5):571-6. doi: 10.1016/j.jcrc.2013.02.009. Epub 2013 Apr 22. J Crit Care. 2013. PMID: 23618779 Free PMC article.
See all "Cited by" articles

MeSH terms

Associated data