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. 2011 Jan;96(1):167-70.
doi: 10.3324/haematol.2010.031831. Epub 2010 Sep 30.

Red blood cell transfusion-dependency implies a poor survival in primary myelofibrosis irrespective of IPSS and DIPSS

Chiara Elena  1 , Francesco Passamonti, Elisa Rumi, Luca Malcovati, Luca Arcaini, Emanuela Boveri, Michele Merli, Daniela Pietra, Cristiana Pascutto, Mario Lazzarino
Affiliations

Red blood cell transfusion-dependency implies a poor survival in primary myelofibrosis irrespective of IPSS and DIPSS

Chiara Elena et al. Haematologica. 2011 Jan.

Abstract

Risk stratification in primary myelofibrosis is currently based on two international prognostic scoring systems, neither of which takes into consideration red blood cell transfusion-dependency. In 288 consecutive patients with primary myelofibrosis, red blood cell transfusion-dependency at diagnosis affects survival independently of the International Prognostic Scoring System (P < 0.001). To evaluate the dynamic impact on survival of red blood cell transfusion-dependency, we performed a Cox's regression analysis with transfusion status as time-dependent covariate in 220 regularly followed patients with primary myelofibrosis. Patients who begin red blood cell transfusions anytime (n = 80, 36%) have a significantly worse survival compared to those who continue follow up without transfusions (HR: 7.8, 95%CI: 5.1-11.9; P < 0.001). Adjusting for Dynamic International Prognostic Scoring System in a multivariate analysis, red blood cell transfusion-dependency retained an independent prognostic impact on survival. This study suggests that red blood cell transfusion-dependency should be considered to improve risk stratification of primary myelofibrosis during follow up.

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Figures

Figure 1.
Figure 1.
Overall survival according to RBC transfusion-dependency at the time of diagnosis in 288 patients with PMF.
Figure 2.
Figure 2.
Overall survival according to RBC transfusion-dependency assessed as a time-dependent variable in 220 regularly followed patients with PMF. Observation started from diagnosis of PMF.
See this image and copyright information in PMC

Comment in

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