Review
doi: 10.1160/TH10-05-0294.
Epub 2010 Sep 30.
Endocytic receptor for pro-coagulant factor VIII: relevance to inhibitor formation
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- PMID: 20886186
- DOI: 10.1160/TH10-05-0294
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Review
Endocytic receptor for pro-coagulant factor VIII: relevance to inhibitor formation
Thromb Haemost.
2010 Dec.
Abstract
The immunogenicity of therapeutic factor VIII (FVIII) in patients with haemophilia A remains a critical issue in patient management. This review describes the immunological processes involved in the activation of the immune system against FVIII, with a particular focus on the role of endocytic receptors for the recognition of FVIII by antigen-presenting cells.
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