Sex, but not repeated maternal separation during the first postnatal week, influences novel object exploration and amphetamine sensitivity
- PMID: 20886535
- DOI: 10.1002/dev.20499
Sex, but not repeated maternal separation during the first postnatal week, influences novel object exploration and amphetamine sensitivity
Abstract
Sensation seeking and early life stress are both risk factors for developing substance use disorders. Neural adaptations resulting from early life stress may mediate individual differences in novelty responsiveness, and, in turn, contribute to drug abuse vulnerability. Animal models also demonstrate associations between novelty responsiveness or early life stress and increased sensitivity to psychostimulants. We investigated whether repeated maternal separation affects responses to novelty during adolescence and to amphetamine during adulthood, and whether maternal separation alters the relationship between these behavioral variables. Rat pups underwent separation (180 min/day) or control procedures (15 min/day) on postnatal days (PND) 2-8. Novel object exploration and amphetamine response were tested at PND 38 and 60, respectively. Adolescent males were less active in a novel environment and approached novel objects more frequently than females, but adult females showed greater amphetamine-induced locomotion. Maternal separation did not affect novelty responsiveness or amphetamine sensitivity. Locomotor activity in an inescapable, novel environment during adolescence predicted amphetamine-induced locomotor activity during adulthood in maternally separated rats, but not in controls. The results of this study suggest that adolescent responses to novelty may be particularly predictive of future substance abuse among survivors of early life trauma. Furthermore, sex differences in novelty and amphetamine responsiveness may complicate the relationship between these behavioral variables.
Copyright © 2010 Wiley Periodicals, Inc.
Similar articles
-
An animal model of sensation seeking: the adolescent rat.Ann N Y Acad Sci. 2004 Jun;1021:453-8. doi: 10.1196/annals.1308.063. Ann N Y Acad Sci. 2004. PMID: 15251928
-
Long-lasting, sex- and age-specific effects of social stressors on corticosterone responses to restraint and on locomotor responses to psychostimulants in rats.Horm Behav. 2005 Jun;48(1):64-74. doi: 10.1016/j.yhbeh.2005.01.008. Horm Behav. 2005. PMID: 15919386
-
Chronic cocaine or ethanol exposure during adolescence alters novelty-related behaviors in adulthood.Pharmacol Biochem Behav. 2007 Apr;86(4):637-42. doi: 10.1016/j.pbb.2007.02.008. Epub 2007 Feb 16. Pharmacol Biochem Behav. 2007. PMID: 17395255
-
Ontogenesis of behavioral sensitization and conditioned place preference induced by psychostimulants in laboratory rodents.Neurosci Biobehav Rev. 2003 Jan-Mar;27(1-2):163-78. doi: 10.1016/s0149-7634(03)00018-6. Neurosci Biobehav Rev. 2003. PMID: 12732232 Review.
-
Peculiar response of adolescent mice to acute and chronic stress and to amphetamine: evidence of sex differences.Behav Brain Res. 2002 Mar 10;130(1-2):117-25. doi: 10.1016/s0166-4328(01)00420-x. Behav Brain Res. 2002. PMID: 11864727 Review.
Cited by
-
Ontogeny of sex differences in response to novel objects from adolescence to adulthood in lister-hooded rats.Dev Psychobiol. 2011 Nov;53(7):670-6. doi: 10.1002/dev.20542. Epub 2011 Mar 31. Dev Psychobiol. 2011. PMID: 21455938 Free PMC article.
-
Developmental programming: cumulative effects of increased pre-hatching corticosterone levels and post-hatching unpredictable food availability on physiology and behaviour in adulthood.Horm Behav. 2013 Aug;64(3):494-500. doi: 10.1016/j.yhbeh.2013.07.002. Epub 2013 Jul 26. Horm Behav. 2013. PMID: 23891687 Free PMC article.
-
Contextual fear conditioning in maternal separated rats: the amygdala as a site for alterations.Neurochem Res. 2014 Feb;39(2):384-93. doi: 10.1007/s11064-013-1230-x. Epub 2013 Dec 25. Neurochem Res. 2014. PMID: 24368626
-
Effects of adolescent methylphenidate administration on methamphetamine conditioned place preference in an animal model of attention-deficit/hyperactivity disorder: Examination of potential sex differences.Drug Alcohol Depend. 2023 Nov 1;252:110970. doi: 10.1016/j.drugalcdep.2023.110970. Epub 2023 Sep 22. Drug Alcohol Depend. 2023. PMID: 37748422 Free PMC article.
-
The effect of early environmental manipulation on locomotor sensitivity and methamphetamine conditioned place preference reward.Behav Brain Res. 2014 Jul 15;268:66-71. doi: 10.1016/j.bbr.2014.03.045. Epub 2014 Apr 5. Behav Brain Res. 2014. PMID: 24713150 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources