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. 2010 Oct 8;7(4):427-8.
doi: 10.1016/j.stem.2010.09.001.

Expansion of human cord blood hematopoietic stem cells for transplantation

Song Chou  1 , Pat Chu, William Hwang, Harvey Lodish
Affiliations

Expansion of human cord blood hematopoietic stem cells for transplantation

Song Chou et al. Cell Stem Cell. .

Abstract

A recent Science paper reported a purine derivative that expands human cord blood hematopoietic stem cells in culture (Boitano et al., 2010) by antagonizing the aryl hydrocarbon receptor. Major problems need to be overcome before ex vivo HSC expansion can be used clinically.

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References

    1. Ahrlund-Richter L, et al. Cell Stem Cell. 2009;4:20–26. - PubMed
    1. Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, et al. Science. 2010 doi: 10.1126/science.1191536. - DOI - PMC - PubMed
    1. Delaney C, Heimfeld S, Brashem-Stein C, Voorhies H, Manger RL, Bernstein ID. Nat Med. 2010;16:232–236. - PMC - PubMed
    1. Foeken LM, Green A, Hurley CK, Marry E, Wiegand T, Oudshoorn M. Bone Marrow Transplant. 2010;45:811–818. - PubMed
    1. Himburg HA, Muramoto GG, Daher P, Meadows SK, Russell JL, Doan P, Chi JT, Salter AB, Lento WE, Reya T, et al. Nat Med. 2010;16:475–482. - PMC - PubMed

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