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Comment
. 2010 Oct 6;12(4):311-312.
doi: 10.1016/j.cmet.2010.09.007.

An IRKO in the Podo: impaired insulin signaling in podocytes and the pathogenesis of diabetic nephropathy

Susan B Gurley  1 , Thomas M Coffman  2
Affiliations
Free article
Comment

An IRKO in the Podo: impaired insulin signaling in podocytes and the pathogenesis of diabetic nephropathy

Susan B Gurley et al. Cell Metab. .
Free article

Abstract

Despite its high prevalence, the mechanisms causing diabetic kidney disease remain poorly understood. In this issue of Cell Metabolism, Welsh et al. (2010) show that elimination of insulin receptors from the glomerular podocyte, a cell that is central to the pathogenesis of proteinuric renal diseases, recapitulates many features of human diabetic nephropathy.

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  • Insulin signaling to the glomerular podocyte is critical for normal kidney function.
    Welsh GI, Hale LJ, Eremina V, Jeansson M, Maezawa Y, Lennon R, Pons DA, Owen RJ, Satchell SC, Miles MJ, Caunt CJ, McArdle CA, Pavenstädt H, Tavaré JM, Herzenberg AM, Kahn CR, Mathieson PW, Quaggin SE, Saleem MA, Coward RJM. Welsh GI, et al. Cell Metab. 2010 Oct 6;12(4):329-340. doi: 10.1016/j.cmet.2010.08.015. Cell Metab. 2010. PMID: 20889126 Free PMC article.

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