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Comment
. 2010 Oct 6;12(4):313-314.
doi: 10.1016/j.cmet.2010.09.006.

Metabolic dysfunction in the pathogenesis of pulmonary hypertension

Lewis J Rubin  1
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Free article
Comment

Metabolic dysfunction in the pathogenesis of pulmonary hypertension

Lewis J Rubin. Cell Metab. .
Free article

Abstract

Pulmonary artery hypertension is characterized by proliferation in the resistance vessels. A recent study in Science Translational Medicine (Sutendra et al., 2010) found that increased fatty acid oxidation and a shift in the glycolysis/glucose oxidation ratio may be central to the pathogenesis of this process, suggesting that these abnormalities comprise novel treatment targets.

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