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Review
. 2010 Dec;12(6):513-21.
doi: 10.1007/s11894-010-0148-6.

Intraepithelial lymphocytes: to serve and protect

Brian S Sheridan  1 , Leo Lefrançois
Affiliations
Review

Intraepithelial lymphocytes: to serve and protect

Brian S Sheridan et al. Curr Gastroenterol Rep. 2010 Dec.

Abstract

The mucosal immune system is constantly exposed to a wide range of commensal and potentially pathogenic microbial species. Chronic exposure to foreign organisms makes generation of an appropriate immune response critical in maintaining a balance between elimination of harmful pathogens, peaceful coexistence with commensals, and prevention of autoimmunity. Intestinal intraepithelial lymphocytes provide a first line of defense at this extensive barrier with the outside world, and as such, understanding their role in immunity is critical.

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References

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