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. 1990 Dec;100(1-2):94-7.
doi: 10.1016/0022-510x(90)90018-i.

Abnormalities of central motor conduction in Parkinson's disease

R H Kandler  1 , J A Jarratt, H J Sagar, E J Gumpert, G S Venables, G A Davies-Jones, N Jordan
Affiliations

Abnormalities of central motor conduction in Parkinson's disease

R H Kandler et al. J Neurol Sci. 1990 Dec.

Abstract

The new technique of magnetic stimulation was used to measure amplitude of the motor evoked potential (MEP) recorded from abductor digiti minimi whilst stimulating at the head, and motor conduction time (MCT) between head and neck. Bilateral studies were made in 12 normal subjects and 56 patients with Parkinson's disease. The amplitudes of the MEPs were significantly larger (P less than 0.05) in the patients (mean 1.6 mV, SD 1.4) compared with the normal subjects (mean 0.9 mV, SE 0.6). MCTs were significantly shorter (P less than 0.001) in patients (mean 8.1 ms, SD 1.3) compared with the normal subjects (mean 9.4 ms, SD 1.2). Although the pathophysiological basis of these changes has not been determined, they provide objective measurements which may be clinically valuable in monitoring therapy.

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