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. 1978 Jul;14(7):616-20.
doi: 10.1007/BF02617921.

Subclones of normal clonal prolactin cells of the rat

H Ishikawa, M Shino, E G Rennels

Subclones of normal clonal prolactin cells of the rat

H Ishikawa et al. In Vitro. 1978 Jul.

Abstract

We recently established a clone (2B8) of normal rat prolactin cells that secretes only prolactin into the medium. When grown in the presence of thyrotrophin-releasing hormone (TRH), estradiol (E2) or arginine vasotocin (AVT), the cells show increased production of prolactin. Subclones of single cell origin were developed from 2B8 cells exposed for 1 week to TRH, E2 or TRH plus E2. These subclones differ in their response to TRH, E2 or AVT and therefore may possess different receptors for these hormones.

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