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. 1978 May;31(5):456-67.
doi: 10.7164/antibiotics.31.456.

Cyclic phosphates of formycin

O Makabe, A Miyadera, M Kinoshita, S Umezawa
Free article

Cyclic phosphates of formycin

O Makabe et al. J Antibiot (Tokyo). 1978 May.
Free article

Abstract

The syntheses of N1- and N2-isopropylformycin (10, 11), formycin 3',5'-cyclic and 2',3'-cyclic phosphate (3,7) and their N-methyl and N-isopropyl derivatives (13, 15, 19, 23) are described. It was observed that substitution at N1 or N2 with a bulky alkyl group or cyclic phosphorylation of the ribose moiety made formycin resistant to adenosine deaminase.

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