Imprinting by DNA methylation: from transgenes to endogenous gene sequences
- PMID: 2090437
Imprinting by DNA methylation: from transgenes to endogenous gene sequences
Abstract
A number of transgenes in the mouse show variation in methylation and expression phenotypes dependent on parental transmission. It appears that there exist at least two types of transgene imprinting; one is retained on an essentially homozygous background, while the other requires heterozygosity at some modifying loci in the genome and is observed as differences in phenotype in reciprocal crosses. For this type of imprinting to occur, the parental origin of the modifier locus itself is important, and parental asymmetry may involve specific interactions between egg cytoplasm and the chromosomes. Based on the identification of 'methylation polymorphism' in the mouse genome, we also show that endogenous gene sequences can undergo imprinting by DNA methylation.
Similar articles
-
A transgene insertional mutation at an imprinted locus in the mouse genome.Dev Suppl. 1990:73-9. Dev Suppl. 1990. PMID: 2090433
-
Genomic imprinting determines methylation of parental alleles in transgenic mice.Nature. 1987 Jul 16-22;328(6127):248-51. doi: 10.1038/328248a0. Nature. 1987. PMID: 3600805
-
Genomic imprinting: cis-acting sequences and regional control.Int Rev Cytol. 2005;243:173-213. doi: 10.1016/S0074-7696(05)43003-X. Int Rev Cytol. 2005. PMID: 15797460 Review.
-
Parent-specific expression of a human keratin 18/beta-galactosidase fusion gene in transgenic mice.Dev Dyn. 1992 Oct;195(2):100-12. doi: 10.1002/aja.1001950204. Dev Dyn. 1992. PMID: 1284293
-
Unequal parental contributions: genomic imprinting in mammals.New Biol. 1989 Nov;1(2):115-20. New Biol. 1989. PMID: 2488703 Review.
Cited by
-
Epigenetic programming and risk: the birthplace of cardiovascular disease?Stem Cell Rev Rep. 2013 Jun;9(3):241-53. doi: 10.1007/s12015-012-9398-z. Stem Cell Rev Rep. 2013. PMID: 22773406 Review.
-
Epigenetic regulation of mesenchymal stem cells: a focus on osteogenic and adipogenic differentiation.Stem Cells Int. 2011;2011:201371. doi: 10.4061/2011/201371. Epub 2011 Jul 11. Stem Cells Int. 2011. PMID: 21772852 Free PMC article.
-
Instability of long inverted repeats within mouse transgenes.EMBO J. 1996 Mar 1;15(5):1163-71. EMBO J. 1996. PMID: 8605887 Free PMC article.
-
Altered Methylation Levels in LINE-1 in Dental Pulp Stem Cell-Derived Osteoblasts.Int Dent J. 2025 Apr;75(2):1269-1276. doi: 10.1016/j.identj.2024.09.009. Epub 2024 Oct 5. Int Dent J. 2025. PMID: 39368926 Free PMC article.
-
Programming the genome in embryonic and somatic stem cells.J Cell Mol Med. 2007 Jul-Aug;11(4):602-20. doi: 10.1111/j.1582-4934.2007.00079.x. J Cell Mol Med. 2007. PMID: 17760828 Free PMC article. Review.