Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Sep 30:7:50.
doi: 10.1186/1476-9255-7-50.

TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients

Ju X Huang #  1 , L Wang #  1 , Ming H Jiang #  2
Affiliations

TNFRSF11B computational development network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients

Ju X Huang et al. J Inflamm (Lond). .

Abstract

Background: TNFRSF11B computational development network construction and analysis of frontal cortex of HIV encephalitis (HIVE) is very useful to identify novel markers and potential targets for prognosis and therapy.

Methods: By integration of gene regulatory network infer (GRNInfer) and the database for annotation, visualization and integrated discovery (DAVID) we identified and constructed significant molecule TNFRSF11B development network from 12 frontal cortex of HIVE-control patients and 16 HIVE in the same GEO Dataset GDS1726.

Results: Our result verified TNFRSF11B developmental process only in the downstream of frontal cortex of HIVE-control patients (BST2, DGKG, GAS1, PDCD4, TGFBR3, VEZF1 inhibition), whereas in the upstream of frontal cortex of HIVE (DGKG, PDCD4 activation) and downstream (CFDP1, DGKG, GAS1, PAX6 activation; BST2, PDCD4, TGFBR3, VEZF1 inhibition). Importantly, we datamined that TNFRSF11B development cluster of HIVE is involved in T-cell mediated immunity, cell projection organization and cell motion (only in HIVE terms) without apoptosis, plasma membrane and kinase activity (only in HIVE-control patients terms), the condition is vital to inflammation, brain morphology and cognition impairment of HIVE. Our result demonstrated that common terms in both HIVE-control patients and HIVE include developmental process, signal transduction, negative regulation of cell proliferation, RNA-binding, zinc-finger, cell development, positive regulation of biological process and cell differentiation.

Conclusions: We deduced the stronger TNFRSF11B development network in HIVE consistent with our number computation. It would be necessary of the stronger TNFRSF11B development function to inflammation, brain morphology and cognition of HIVE.

PubMed Disclaimer

Figures

Figure 1
Figure 1
TNFRSF11B up- and down-stream development cluster in frontal cortex of HIVE-control patients by DAVID (A, C). TNFRSF11B up- and down-stream development cluster by DAVID in frontal cortex of HIVE (B, D). Gray color represents gene-term association positively reported, black color represents gene-term association not reported yet.
Figure 2
Figure 2
TNFRSF11B up- and down-stream development network construction in frontal cortex of HIVE-control patients by infer (A, C). TNFRSF11B up- and down-stream development network construction in frontal cortex of HIVE by infer (B, D). Arrowhead represents activation, empty cycle represents inhibition.
See this image and copyright information in PMC

References

    1. Masliah E, Roberts ES, Langford D, Everall I, Crews L, Adame A, Rockenstein E, Fox HS. Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis. J Neuroimmunol. 2004;157:163–175. doi: 10.1016/j.jneuroim.2004.08.026. - DOI - PubMed
    1. Chang L, Wang GJ, Volkow ND, Ernst T, Telang F, Logan J, Fowler JS. Decreased brain dopamine transporters are related to cognitive deficits in HIV patients with or without cocaine abuse. Neuroimage. 2008;42:869–878. doi: 10.1016/j.neuroimage.2008.05.011. - DOI - PMC - PubMed
    1. Descamps M, Hyare H, Stebbing J, Winston A. Magnetic resonance imaging and spectroscopy of the brain in HIV disease. J HIV Ther. 2008;13:55–58. - PubMed
    1. Georgiou MF, Gonenc A, Waldrop-Valverde D, Kuker RA, Ezuddin SH, Sfakianakis GN, Kumar M. Analysis of the effects of injecting drug use and HIV-1 infection on 18F-FDG PET brain metabolism. J Nucl Med. 2008;49:1999–2005. doi: 10.2967/jnumed.108.052688. - DOI - PubMed
    1. Beyens G, Daroszewska A, de Freitas F, Fransen E, Vanhoenacker F, Verbruggen L, Zmierczak HG, Westhovens R, Van Offel J, Ralston SH. et al.Identification of sex-specific associations between polymorphisms of the osteoprotegerin gene, TNFRSF11B, and Paget's disease of bone. J Bone Miner Res. 2007;22:1062–1071. doi: 10.1359/jbmr.070333. - DOI - PubMed

LinkOut - more resources